The bulk of Friday's cancellations are in Charlotte and Raleigh, North Carolina.
Airlines have canceled all flights in and out of Philadelphia International Airport on Saturday. They'll cancel operations in Washington, D.C., and Baltimore on Saturday.
Airport officials urged all travelers to check with their airlines before heading to the airport.
Consumerist lists the airlines issuing advisories and waivers for customers who might find their plans thwarted by the storm. A full list of cancelled flights by airline and airport is available on FlyAware.
A total of 59 flights were canceled at SFO, and the average flight delay, as of 7 a.m., was more than three hours, the FAA's flight tracker system reported.
There are a little more than 22,000 flights scheduled to, from, or even within the United States, according to FlightAware.
If you are flying, it is advised to call the airline before you head to the airport. Saturday travel looked no better, with 3,458 flights canceled in advance.
American Airlines has canceled all flights arriving and departing from Charlotte, including six flights from PBIA and 15 flights from Fort Lauderdale.
The carrier also says it is reviewing its Saturday services to and from New York's Newark and JFK, but warns of "significant disruption to our schedules".
"We have a maintenance and operational department that is prepared and trained on how to handle winter weather and what to do to keep our runway open and operational", Alexandra Bradley, with Asheville Regional Airport, said.
"Contact your airline early and often", Davis said, adding that airlines ultimately make the decision to cancel a flight.
Olivia Howard is visiting San Diego from Tennessee with her brothers and sister, and found out their flight was canceled. You'll pay long-distance rates, but might not have to wait.
Since many airlines had a heads-up before the storm, some representatives were able to offer travelers different options. Warning: Many of the rooms are nonrefundable when booked, so lock in only once you are stuck.
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